CTMM is a €300M Dutch public-private consortium that comprises a multidisciplinary group of parties – universities, academic medical centers, medical technology enterprises and chemical and pharmaceutical companies, and which aims to accelerate translational medicine by improving diagnosis. The Hyve is an active member of the CTMM Translational Research IT (TraIT) project, which aims to develop a long-lasting IT infrastructure for the Netherlands that will facilitate the collection, storage, analysis, archiving and securing of the data generated in the CTMM’s twenty-one disease area focused operational research projects.
In the context of TraIT, we primarily work on data integration, data harmonization and import of the multitude of datasets generated by the disease projects, using open source tools such as tranSMART, i2b2, OpenClinica, BMIA, XNAT, Galaxy, Molgenis, Phenotype Database and cBioPortal. Data integration is this context means the integration of clinical, biobanking, imaging and experimental data into a single data sharing environment. The biobanking data component brings together data from several initiatives, including Strings of Pearl (Parelsnoer), Lifelines and BBMRI.
Key challenges here that we have worked on are the authentication and authorization workflow to share data, ensuring data reproducibility, ensuring patient privacy (via i2b2 and tools such as CTP) and semantic data integration. This work is done in a multidisciplinary team with people from Philips Research, The Hyve and various academic hospitals (such as VUmc, UMC, ErasmusMC and UMCG), and led by The Hyve. The integration, normalization, and alignment of data in i2b2 and tranSMART permits users from the CTMM disease projects to explore and share data very efficiently to formulate new research strategies.
Please get in contact to see how we can support your bioinformatics project.
Read all our blog posts on the CTMM TraIT project in our News section.