IMI EHDEN is building a European Health Data Network

The European Health Data & Evidence Network (EHDEN) is one of the flagship projects of the Innovative Medicines Initiative (IMI) and a pillar of the European OHDSI community. Together with 21 partners from academia, regulatory bodies, governments, NGOs and industry, The Hyve aims at leveraging the potential of real world data and large-scale analysis to build a federated data network, allowing access to the medical data of EU citizens standardised to the OMOP common data model.

The challenge

The main question addressed by the EHDEN consortium is: How can the huge amount of observational health data and medical history data from EU citizens be leveraged to study patient level and population level health?

How EHDEN is addressing it

The EHDEN consortium addresses this question from five angles: Harmonisation, Federation, Community, Education and Outcomes.

Harmonisation of real world data to a common standard (OMOP CDM) enables federated analysis with the large-scale analytics tools provided by the OHDSI suite. However, scaling these up to a European level is only possible through education and a growing community. The combination of those factors will lead to outcome-driven healthcare improvements on a European level.

Since the available amount of real world data is huge and continues to grow every day, it is impossible for the current EHDEN consortium members to harmonize all data. Therefore, new community members are trained to help realize this ambitious task. Besides training, EHDEN also provides funding for data owners who want to have their data converted to OMOP and to participate in the ever growing federated data network.

Within the consortium, The Hyve is co-leading the technical work package, in which we coordinate design, set up and implementation of the EHDEN infrastructure (e.g. EHDEN portal to identify data sources of interest) and actively improve ETL tools of the OHDSI tool suite. Our OMOP experts are also sharing their knowledge with the community by training other SMEs (small and medium enterprises) on best practises of OMOP conversions.

The Hyve is the lead contributor to the EHDEN deliverable called Roadmap for interoperability solutions, which explains the use of the OMOP CDM in EHDEN and its relation to other biomedical standards, such as i2b2, CDISC, FHIR, openEHR and GA4GH.

The Outcome

Even though the project is still ongoing, already a number of great results can be reported. One of them being the high number of EU citizen’s health records that have been converted to the OMOP CDM and are therefore available for federated analysis. In January 2021, the IMI EHDEN consortium reached 200 million European patient records, doubling the initial project goal.

Besides the growing number of available health records in the OMOP CDM, the rapidly growing community is another success of EHDEN. In 2021, 62 data partners from all over Europe were granted funding to map their data to the OMOP CDM and make it available to the network. To execute the conversion, more than 20 SMEs have been trained by a team of OMOP experts from The Hyve and other organisations in the EHDEN framework.


The OHDSI suite is an open-source, modular solution that enables organizations to explore 360° patient journeys and turn data into evidence. The ecosystem provides a broad range of tools that cover all aspects of real world data and evidence − from data characterization to a standardized data model (OMOP CDM). This enables large scale cross-database analytics with OHDSI.

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What people say about The Hyve

"The Hyve is one of Europe’s leading technology IT services providers who have established an international reputation within the biomedical informatics domain, from open standards such as OHDSI to working with FAIR principles. With their passionate leadership, they have been involved in numerous projects including the European Health Data & Evidence Network (EHDEN). I have no doubt that all of these projects have benefited greatly from their thinking, insights and hands-on expertise."

Nigel Hughes, Industry Lead at IMI EHDEN Project

"The workshops provided by The Hyve were very helpful to understand and perform all the processes needed to transform our cohort data into the common data model (OMOP) and use the cutting-edge OHDSI tools for analyzing observational studies. We are glad to have been introduced to the OHDSI real-world data platform and networks by the experts of The Hyve."

Alexis Sentís Fuster, Epidemiologist at Centre for Epidemiological Studies of Sexually Transmitted Disease and AIDS in Catalonia (CEEISCAT)

"A few years ago, we decided to invest in our institute-wide registry for patients and samples and make that data available to all researchers within our institute. We pursued this avenue together with The Hyve and they have been a tremendous help in developing new features, thinking about possible solutions and maintaining the platform.”

Patrick Kemmeren, Principal Investigator at Princess Máxima Center for Pediatric Oncology

"The Hyve is the clear choice for institutions looking to maximize the value and impact of their OMOP CDM. Working directly with the maintainers of the OHDSI software tools we use at TrialSpark was a great learning experience that also resulted in tangible improvements to our data quality and analytics tooling. The Hyve engineers' curiosity and dedication is an inspiration to our team and to the broader OHDSI community."

Katy Sadowski, Technical Product Manager at TrialSpark

Engage with our OHDSI team

  • Our mapping experts can work with EHR, EMR, registry data and most popular commercial / claims datasets.
  • Training all the new mapping service providers in EU (EHDEN)
  • Integrating OHDSI with semantic standards

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