Target discovery

Target identification, validation and prioritization using a user-friendly platform

The problem

Drug development pipelines suffer from increasings costs and declining success rates. More than half of the failures can be explained by lack of efficacy, of which almost half can be explained by poor linkage between target and disease. Selecting better targets can double the success rate of the drug development pipeline.

How The Hyve can help

The Open Targets Platform is an open-source web-based platform, that integrates multiple data sources of various types. It features a scoring algorithm on target-disease associations to help you to identify, validate and prioritize drug targets for further research. The Open Targets Genetics Platform allows you to discover associations between genes, variants and traits, and integrates well with the Open Targets Platform.

We help our clients by supporting these tools and are working with two of the Open Targets consortium partners to implement them within their organization. In addition, three other pharma companies, outside of the consortium, have expressed an interest to work with Open Targets in the near future.

Open Targets

Welcome to The Hyve and elevate your drug discovery process with the Open Targets target platform and genetics portal—essential tools for identifying and validating drug targets. The Open Targets Platform is a powerful, open-source web tool that seamlessly integrates diverse data sources, providing comprehensive insights at your fingertips. Furthermore, with the Open Targets Genetics Portal, you can unlock groundbreaking associations between genes, variants, and traits using GWAS data, revolutionising your approach to target discovery.

The Hyve initiated collaboration with the Open Targets consortium in 2018 and has been actively contributing to the code base, managing multiple private Open Targets installations worldwide.