cBioPortal
cBioPortal is an open-source platform that makes large-scale cancer genomics datasets accessible to researchers and clinicians. At The Hyve, we help pharmaceutical companies, hospitals, research institutions, and data providers unlock the full potential of cBioPortal by enabling secure, integrated analysis of both public and proprietary data tailored to their research needs. As a trusted contributor to the cBioPortal community since 2015, we combine deep technical expertise with hands-on experience to ensure smooth deployment, seamless integration, and actionable insights from your biomedical data.
cBioPortal SaaS delivers a secure, scalable, fully managed cBioPortal environment with hosted deployment, private data loading, access & identity management, and enablement, so you analyse clinico‑genomic data without infrastructure or DevOps.
We install cBioPortal securely within your infrastructure or manage a cloud-based instance on your behalf. Study-level authorization ensures role-based access to specific sensitive datasets within your environment.
Our team handles the entire data-loading process, ensuring your cancer genomics data is prepared, validated, and uploaded using best practices aligned with cBioPortal’s data standards. This allows your researchers to focus on analysis rather than technical setup.
If cBioPortal does not fully match your use case, we develop custom features tailored to your research needs. Our solutions expand the platform’s capabilities and, where relevant, will be contributed back to the open-source community, amplifying impact beyond your organization.
We offer tailored, hands-on end-user training designed to help your team fully leverage cBioPortal’s capabilities, focusing on your specific datasets and research goals.
Our experts help you define, optimize, and integrate cBioPortal into your workflows, be it in a research or clinical setting. Through tailored advice, we ensure the platform aligns with your needs and helps you reach critical insights and your research goals.
We ensure your proprietary data remains secure with customized deployment on your infrastructure, with advanced access controls, study-level authorization, and auditability.
From seamless data loading managed by our experts to training your bioinformaticians, we offer comprehensive solutions tailored to your needs.
Stay ahead with our ongoing development of new functionalities specifically designed for your unique use cases. We continually develop new functionalities and enhancements tailored to the evolving needs of research.
Empower your team with customized end-user training that enables efficient data loading and effective exploration of your datasets.
Our consultancy services offer strategic advice for seamless integration with other platforms, ensuring your organization maximizes the full benefits of cBioPortal.
Benefit from early access to new features, opportunities for collaboration with leading experts, and the ability to shape best practices in cancer genomics research.
Intuitive and interactive visualizations simplify the interpretation of complex genomic datasets.
Compare your results with nearly 500 curated public studies already available in cBioPortal, including datasets from TCGA, ICGC, publications and other major consortia.
Become a power user by using OQL to do advanced comparisons in cBioPortal. The Hyve recently developed the AI OQL Helper that writes queries for you and unlocks this powerful feature to those not familiar with OQL.
As well as support from The Hyve, cBioPortal is part of an active community that is always willing to think along with you to find a solution to your problem.
As a valued partner in advancing cancer research, we’re thrilled to share the latest updates and innovations from the cBioPortal community and The Hyve. Whether you’re a researcher, data scientist, or healthcare professional, there’s something here to inspire and empower your work. Let’s dive in!
The Hyve has supported many leading pharmaceutical companies, research institutes and hospitals in transforming complex cancer genomics data into actionable insights. From improving survival analysis to accelerating target discovery, our cBioPortal solutions help teams solve real-world challenges in oncology research.
“We are excited to be building an open-source community around cBioPortal, and The Hyve has become an integral part of our efforts. The Hyve brings unique expertise in building open-source bioinformatics platforms, and in building bridges between academic centers and industry. We look forward to continued work together.”
Ethan Cerami, Director, Knowledge Systems Group, Department of Biostatistics and Computational Biology at Dana-Farber Cancer Institute“Over the past years, The Hyve has constituted many important new features to cBioPortal, and their quality has always exceeded our expectations. We look forward to collaborating more and are excited to have them as a partner that can help us build bridges to pharmaceutical companies and other academic centers.”
Nikolaus Schultz, Head of Knowledge Systems, Marie-Josée & Henry R. Kravis Center for Molecular Oncology at Memorial Sloan Kettering Cancer Center"A few years ago, we decided to invest in our institute-wide registry for patients and samples and make that data available to all researchers within our institute. We pursued this avenue together with The Hyve and they have been a tremendous help in developing new features, thinking about possible solutions and maintaining the platform.”
Patrick Kemmeren, Principal Investigator at Princess Máxima Center for Pediatric Oncology"We wanted to invest in developing a platform to help better visualize our data for both internal and external uses, and we are very glad we chose to collaborate with The Hyve. They have been extraordinary partners in helping us develop personalized solutions for our data, problem-solving, and helping us realize our vision. We look forward to our continued relationship and what we will create together."
Reagan Barnett, Ph.D., Medical Science Liaison, Medical Affairs at Guardant HealthWhat is the difference between cBioPortal's public and private deployments?
A public cBioPortal deployment, such as the instance hosted by Memorial Sloan Kettering Cancer Center (MSKCC), provides open access to a range of publicly available cancer genomics datasets. These deployments are designed to support the global research community by offering curated data from sources like The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC).
In contrast, a private cBioPortal deployment is hosted within an organization’s own infrastructure and is accessible only to authorized users. This allows institutions to load, manage, and analyze proprietary datasets — including unpublished research or patient-specific clinical data — in a secure environment, fully aligned with internal data governance policies.
What types of use cases can cBioPortal support?
cBioPortal can be applied to a wide variety of research and clinical scenarios, including:
Public Deployments:
Ideal for hypothesis generation, educational purposes, benchmarking new algorithms, or validating research findings against public datasets.
Private Deployments:
Suited for organizations looking to integrate internal clinical or research data, collaborate across institutions, develop targeted therapies, or support personalized treatment decisions using sensitive genomic data in a secure and controlled setting.
How secure is a private cBioPortal deployment?
A private cBioPortal deployment offers complete control over data access and security. With study-level authorization, encrypted communication, and deployment within your institution’s infrastructure, the platform meets the highest standards for data governance and privacy compliance. The Hyve’s team can advise on best practices for integrating cBioPortal into secure environments that comply with regulatory frameworks such as GDPR or HIPAA.